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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | SO | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Miguel Sano# | 219 | 2016 | |
| 2 | Justin Upton# | 176 | 2016 | |
| 3 | Christian Yelich# | 160 | 2016 | |
| 4 | Khris Davis# | 145 | 2016 | |
| 4 | Starling Marte# | 145 | 2016 | |
| 6 | Randal Grichuk# | 143 | 2016 | |
| 7 | Michael Saunders# | 135 | 2016 | |
| 8 | Kyle Schwarber# | 134 | 2016 | |
| 9 | Ryan Braun# | 118 | 2016 | |
| 9 | Michael Conforto# | 118 | 2016 | |
| 11 | David Peralta# | 117 | 2016 | |
| 12 | Franklin Gutierrez# | 115 | 2016 | |
| 13 | Jackie Bradley Jr.# | 114 | 2016 | |
| 14 | Andre Ethier# | 92 | 2016 | |
| 14 | Kevin Pillar# | 92 | 2016 | |
| 16 | Nelson Cruz# | 91 | 2016 | |
| 17 | Coco Crisp# | 71 | 2016 | |
| 18 | Yoenis Cespedes# | 64 | 2016 | |
| 19 | Michael Brantley# | 59 | 2016 |
