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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| CC Sabathia | 2016-2016 | .000 | 0 | 0 | 5 | 9 | 0 | 6.72 | 35 |
| Danny Salazar | 2016-2017 | .000 | 0 | 0 | 13 | 12 | 0 | 4.34 | 242 |
| Chris Sale | 2016-2017 | .000 | 0 | 0 | 17 | 10 | 0 | 3.63 | 235 |
| Jarrod Saltalamacchia | 2016-2016 | .299 | 6 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Jeff Samardzija | 2016-2017 | .000 | 0 | 0 | 17 | 14 | 0 | 4.54 | 179 |
| Keyvius Sampson | 2016-2016 | .000 | 0 | 0 | 3 | 9 | 0 | 6.23 | 72 |
| Aaron Sanchez | 2016-2017 | .000 | 0 | 0 | 6 | 10 | 0 | 5.34 | 97 |
| Anibal Sanchez | 2016-2016 | .000 | 0 | 0 | 11 | 9 | 0 | 4.31 | 156 |
| Gaby Sanchez | 2016-2017 | .321 | 3 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Miguel Sano | 2016-2017 | .218 | 41 | 110 | 0 | 0 | 0 | 0.00 | 0 |
| Carlos Santana | 2016-2016 | .216 | 8 | 42 | 0 | 0 | 0 | 0.00 | 0 |
| Domingo Santana | 2016-2016 | .232 | 5 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Ervin Santana | 2016-2016 | .000 | 0 | 0 | 8 | 18 | 0 | 6.56 | 57 |
| Mario Santiago | 2017-2017 | .000 | 0 | 0 | 3 | 1 | 0 | 6.54 | 17 |
| Sergio Santos | 2016-2016 | .000 | 0 | 0 | 0 | 1 | 1 | 3.86 | 19 |
| Michael Saunders | 2016-2017 | .277 | 14 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Max Scherzer | 2016-2017 | .000 | 0 | 0 | 14 | 7 | 0 | 3.06 | 156 |
| Jonathan Schoop | 2016-2017 | .266 | 26 | 93 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Schwarber | 2016-2017 | .259 | 31 | 78 | 0 | 0 | 0 | 0.00 | 0 |
| Corey Seager | 2016-2017 | .292 | 18 | 87 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Seager | 2016-2017 | .243 | 13 | 73 | 0 | 0 | 0 | 0.00 | 0 |
| Jean Segura | 2017-2017 | .325 | 1 | 10 | 0 | 0 | 0 | 0.00 | 0 |
| Marcus Semien | 2016-2017 | .252 | 6 | 31 | 0 | 0 | 0 | 18.00 | 0 |
| Luis Severino | 2016-2016 | .000 | 0 | 0 | 0 | 0 | 0 | 5.40 | 4 |
| Travis Shaw | 2016-2017 | .144 | 4 | 14 | 0 | 0 | 0 | 0.00 | 0 |
| James Shields | 2016-2016 | .000 | 0 | 0 | 2 | 3 | 0 | 6.59 | 31 |
| Matt Shoemaker | 2016-2016 | .000 | 0 | 0 | 10 | 2 | 1 | 2.67 | 77 |
| Chasen Shreve | 2016-2017 | .000 | 0 | 0 | 4 | 2 | 5 | 2.73 | 107 |
| J.B. Shuck | 2016-2016 | 1.000 | 1 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Kevin Siegrist | 2016-2017 | .000 | 0 | 0 | 3 | 6 | 3 | 5.42 | 118 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Andrelton Simmons | 2016-2017 | .245 | 4 | 41 | 0 | 0 | 0 | 0.00 | 0 |
| Tony Sipp | 2016-2016 | .000 | 0 | 0 | 3 | 5 | 1 | 4.16 | 72 |
| Carson Smith | 2016-2017 | .000 | 0 | 0 | 5 | 4 | 3 | 2.58 | 100 |
| Joe Smith | 2016-2016 | .000 | 0 | 0 | 2 | 1 | 2 | 5.07 | 41 |
| Will Smith | 2016-2017 | .000 | 0 | 0 | 7 | 5 | 7 | 2.77 | 135 |
| Josh Smoker | 2016-2016 | .000 | 0 | 0 | 1 | 2 | 1 | 3.60 | 47 |
| Drew Smyly | 2016-2017 | .000 | 0 | 0 | 4 | 5 | 2 | 4.20 | 115 |
| Yangervis Solarte | 2016-2017 | .302 | 9 | 73 | 0 | 0 | 0 | 0.00 | 0 |
| Jorge Soler | 2016-2017 | .237 | 20 | 72 | 0 | 0 | 0 | 0.00 | 0 |
| Joakim Soria | 2016-2016 | .000 | 0 | 0 | 2 | 1 | 1 | 4.91 | 19 |
| Geovany Soto | 2016-2016 | .200 | 0 | 0 | 0 | 0 | 0 | 0.00 | 2 |
| Steven Souza Jr. | 2016-2016 | .247 | 6 | 21 | 0 | 0 | 0 | 0.00 | 0 |
| Denard Span | 2016-2017 | .282 | 4 | 41 | 0 | 0 | 0 | 0.00 | 0 |
| Cory Spangenberg | 2016-2017 | .282 | 8 | 75 | 0 | 0 | 0 | 0.00 | 0 |
| George Springer | 2016-2017 | .217 | 25 | 87 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Squier | 2016-2017 | .184 | 1 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Giancarlo Stanton | 2016-2017 | .246 | 36 | 103 | 0 | 0 | 0 | 0.00 | 0 |
| Drew Storen | 2016-2017 | .000 | 0 | 0 | 1 | 1 | 1 | 3.23 | 29 |
| Stephen Strasburg | 2016-2017 | .000 | 0 | 0 | 14 | 21 | 0 | 3.83 | 259 |
| Huston Street | 2016-2017 | .000 | 0 | 0 | 0 | 4 | 6 | 4.00 | 90 |
| Hunter Strickland | 2016-2017 | .000 | 0 | 0 | 2 | 9 | 6 | 4.09 | 78 |
| Marcus Stroman | 2016-2017 | .000 | 0 | 0 | 17 | 14 | 0 | 3.01 | 228 |
| Pedro Strop | 2016-2017 | .000 | 0 | 0 | 4 | 5 | 3 | 4.50 | 87 |
| Daniel Stumpf | 2017-2017 | .000 | 0 | 0 | 3 | 3 | 0 | 4.65 | 17 |
| Eugenio Suarez | 2016-2017 | .254 | 15 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Andrew Susac | 2016-2016 | .206 | 2 | 9 | 0 | 0 | 0 | 0.00 | 0 |
| Ichiro Suzuki | 2016-2017 | .289 | 4 | 40 | 0 | 0 | 0 | 0.00 | 0 |
| Kurt Suzuki | 2016-2017 | .194 | 1 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Blake Swihart | 2016-2017 | .278 | 12 | 57 | 0 | 0 | 0 | 0.00 | 0 |
| Noah Syndergaard | 2016-2017 | .000 | 0 | 0 | 17 | 9 | 0 | 2.78 | 293 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
