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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| CC Sabathia | 2016-2016 | .000 | 0 | 0 | 7 | 1 | 0 | 2.28 | 83 |
| Blake Sabol | 2016-2017 | .148 | 0 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Tyler Saladino | 2016-2017 | .215 | 16 | 69 | 0 | 0 | 0 | 0.00 | 0 |
| Fernando Salas | 2016-2016 | .000 | 0 | 0 | 6 | 7 | 29 | 2.21 | 88 |
| Edward Salcedo | 2016-2017 | .288 | 17 | 68 | 0 | 0 | 0 | 0.00 | 0 |
| Georgie Salem | 2016-2016 | .229 | 3 | 13 | 0 | 0 | 0 | 0.00 | 0 |
| Jarrod Saltalamacchia | 2017-2017 | .265 | 1 | 4 | 0 | 0 | 0 | 0.00 | 0 |
| Keyvius Sampson | 2016-2017 | .000 | 0 | 0 | 10 | 6 | 0 | 3.38 | 171 |
| Anibal Sanchez | 2017-2017 | .000 | 0 | 0 | 6 | 1 | 0 | 2.47 | 53 |
| Gaby Sanchez | 2016-2017 | .232 | 17 | 57 | 0 | 0 | 0 | 0.00 | 0 |
| Pablo Sandoval | 2016-2016 | .248 | 8 | 42 | 0 | 0 | 0 | 0.00 | 0 |
| Jerry Sands | 2016-2016 | .253 | 2 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Carlos Santana | 2016-2017 | .256 | 11 | 35 | 0 | 0 | 0 | 0.00 | 0 |
| Danny Santana | 2016-2017 | .239 | 1 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Domingo Santana | 2016-2017 | .221 | 9 | 27 | 0 | 0 | 0 | 0.00 | 0 |
| Ervin Santana | 2017-2017 | .000 | 0 | 0 | 0 | 2 | 0 | 6.62 | 18 |
| Mario Santiago | 2016-2016 | .000 | 0 | 0 | 3 | 0 | 2 | 2.11 | 54 |
| Sergio Santos | 2016-2016 | .000 | 0 | 0 | 1 | 4 | 8 | 3.00 | 72 |
| Michael Saunders | 2016-2016 | .403 | 5 | 19 | 0 | 0 | 0 | 0.00 | 0 |
| Scott Schebler | 2016-2017 | .252 | 9 | 55 | 0 | 0 | 0 | 0.00 | 0 |
| Tanner Scheppers | 2016-2017 | .000 | 0 | 0 | 1 | 1 | 3 | 4.68 | 87 |
| Andrew Schmidt | 2016-2017 | .175 | 1 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Austin Schotts | 2016-2017 | .222 | 0 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| John Schreiber | 2016-2017 | .000 | 0 | 0 | 2 | 1 | 0 | 7.05 | 41 |
| Evan Scribner | 2016-2017 | .000 | 0 | 0 | 2 | 4 | 4 | 3.92 | 111 |
| Chad Sedio | 2016-2016 | .284 | 9 | 22 | 0 | 0 | 0 | 0.00 | 0 |
| Jean Segura | 2016-2017 | .313 | 1 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Steven Sensley | 2016-2016 | .262 | 0 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Nick Senzel | 2016-2016 | .000 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Brian Serven | 2016-2017 | .191 | 4 | 32 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Bryan Shaw | 2016-2016 | .000 | 0 | 0 | 3 | 4 | 2 | 3.47 | 73 |
| Travis Shaw | 2016-2016 | .243 | 3 | 15 | 0 | 0 | 0 | 0.00 | 0 |
| Michael Shawaryn | 2017-2017 | .000 | 0 | 0 | 2 | 0 | 1 | 2.57 | 16 |
| Jordan Sheffield | 2016-2017 | .000 | 0 | 0 | 3 | 6 | 0 | 5.51 | 64 |
| JaVon Shelby | 2017-2017 | .221 | 0 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| James Shields | 2016-2016 | .000 | 0 | 0 | 2 | 0 | 1 | 2.60 | 24 |
| Matt Shoemaker | 2016-2017 | .000 | 0 | 0 | 8 | 4 | 0 | 2.99 | 80 |
| J.B. Shuck | 2016-2017 | .261 | 1 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| Nick Shumpert | 2016-2016 | .194 | 1 | 16 | 0 | 0 | 0 | 0.00 | 0 |
| Kevin Siegrist | 2016-2016 | .000 | 0 | 0 | 1 | 2 | 5 | 2.03 | 48 |
| Yaisel Sierra | 2016-2017 | .000 | 0 | 0 | 12 | 18 | 0 | 4.42 | 276 |
| Adam Simmons | 2016-2017 | .233 | 4 | 28 | 0 | 0 | 0 | 0.00 | 0 |
| Shae Simmons | 2016-2017 | .000 | 0 | 0 | 8 | 6 | 4 | 2.68 | 136 |
| Alfredo Simon | 2016-2016 | .000 | 0 | 0 | 14 | 14 | 0 | 4.09 | 148 |
| Jon Singleton | 2016-2017 | .216 | 30 | 84 | 0 | 0 | 0 | 0.00 | 0 |
| Andy Sisco | 2016-2016 | .000 | 0 | 0 | 0 | 0 | 0 | 2.25 | 13 |
| Joe Smith | 2016-2017 | .000 | 0 | 0 | 2 | 0 | 8 | 2.57 | 26 |
| Josh Smith | 2017-2017 | .129 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Marquez Smith | 2016-2017 | .250 | 11 | 63 | 0 | 0 | 0 | 0.00 | 0 |
| Seth Smith | 2016-2017 | .253 | 14 | 57 | 0 | 0 | 0 | 0.00 | 0 |
| Steve Smith | 2016-2016 | .000 | 0 | 0 | 3 | 4 | 1 | 5.36 | 53 |
| Justin Smoak | 2016-2017 | .259 | 17 | 75 | 0 | 0 | 0 | 0.00 | 0 |
| Josh Smoker | 2016-2017 | .000 | 0 | 0 | 2 | 4 | 10 | 2.45 | 71 |
| Eric Sogard | 2016-2016 | .297 | 0 | 8 | 0 | 0 | 0 | 0.00 | 0 |
| Joakim Soria | 2016-2017 | .000 | 0 | 0 | 1 | 3 | 3 | 2.55 | 81 |
| Geovany Soto | 2016-2016 | .202 | 8 | 26 | 0 | 0 | 0 | 0.00 | 0 |
| Steven Souza Jr. | 2016-2017 | .264 | 13 | 58 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Squier | 2016-2016 | .284 | 4 | 12 | 0 | 0 | 0 | 0.00 | 0 |
| Ford Stainback | 2017-2017 | .267 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Max Stassi | 2016-2017 | .269 | 2 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Tim Stauffer | 2016-2016 | .000 | 0 | 0 | 3 | 0 | 1 | 4.35 | 54 |
| Robert Stephenson | 2016-2017 | .000 | 0 | 0 | 6 | 4 | 0 | 2.70 | 107 |
| John Sternagel | 2016-2017 | .212 | 5 | 42 | 0 | 0 | 0 | 0.00 | 0 |
| Will Stillman | 2017-2017 | .000 | 0 | 0 | 0 | 0 | 0 | 5.30 | 20 |
| Drew Storen | 2016-2016 | .000 | 0 | 0 | 1 | 1 | 7 | 0.69 | 13 |
| Trevor Story | 2016-2017 | .254 | 26 | 110 | 0 | 0 | 0 | 0.00 | 0 |
| Dan Straily | 2016-2016 | .000 | 0 | 0 | 0 | 1 | 0 | 3.25 | 40 |
| Gavin Stupienski | 2017-2017 | .250 | 2 | 6 | 0 | 0 | 0 | 0.00 | 0 |
| Alixon Suarez | 2016-2017 | .100 | 2 | 5 | 0 | 0 | 0 | 0.00 | 0 |
| Eugenio Suarez | 2016-2016 | .315 | 8 | 43 | 0 | 0 | 0 | 0.00 | 0 |
| Jack Sundberg | 2016-2017 | .165 | 2 | 22 | 0 | 0 | 0 | 0.00 | 0 |
| Andrew Susac | 2016-2017 | .252 | 9 | 46 | 0 | 0 | 0 | 0.00 | 0 |
| Blake Swihart | 2016-2016 | .259 | 4 | 23 | 0 | 0 | 0 | 0.00 | 0 |
| Nick Swisher | 2016-2016 | .257 | 14 | 47 | 0 | 0 | 0 | 0.00 | 0 |
