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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
|---|---|---|---|---|---|---|---|---|---|
| CC Sabathia | 2016-2016 | .000 | 0 | 0 | 5 | 9 | 0 | 6.72 | 35 |
| Tyler Saladino | 2017-2017 | .091 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0 |
| Danny Salazar | 2016-2017 | .000 | 0 | 0 | 18 | 17 | 0 | 4.34 | 300 |
| Chris Sale | 2016-2017 | .000 | 0 | 0 | 19 | 14 | 0 | 3.62 | 285 |
| Jarrod Saltalamacchia | 2016-2016 | .299 | 6 | 17 | 0 | 0 | 0 | 0.00 | 0 |
| Jeff Samardzija | 2016-2017 | .000 | 0 | 0 | 22 | 15 | 0 | 4.26 | 230 |
| Keyvius Sampson | 2016-2016 | .000 | 0 | 0 | 3 | 9 | 0 | 6.23 | 72 |
| Aaron Sanchez | 2016-2017 | .000 | 0 | 0 | 11 | 13 | 0 | 5.16 | 147 |
| Anibal Sanchez | 2016-2016 | .000 | 0 | 0 | 11 | 9 | 0 | 4.31 | 156 |
| Gaby Sanchez | 2016-2017 | .313 | 3 | 11 | 0 | 0 | 0 | 0.00 | 0 |
| Miguel Sano | 2016-2017 | .224 | 51 | 139 | 0 | 0 | 0 | 0.00 | 0 |
| Carlos Santana | 2016-2017 | .216 | 12 | 64 | 0 | 0 | 0 | 0.00 | 0 |
| Domingo Santana | 2016-2017 | .226 | 5 | 14 | 0 | 0 | 0 | 0.00 | 0 |
| Ervin Santana | 2016-2016 | .000 | 0 | 0 | 8 | 18 | 0 | 6.56 | 57 |
| Mario Santiago | 2017-2017 | .000 | 0 | 0 | 4 | 5 | 0 | 7.45 | 34 |
| Sergio Santos | 2016-2016 | .000 | 0 | 0 | 0 | 1 | 1 | 3.86 | 19 |
| Michael Saunders | 2016-2017 | .277 | 14 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Max Scherzer | 2016-2017 | .000 | 0 | 0 | 16 | 8 | 0 | 3.24 | 172 |
| Jonathan Schoop | 2016-2017 | .268 | 35 | 124 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Schwarber | 2016-2017 | .248 | 39 | 103 | 0 | 0 | 0 | 0.00 | 0 |
| Corey Seager | 2016-2017 | .298 | 24 | 116 | 0 | 0 | 0 | 0.00 | 0 |
| Kyle Seager | 2016-2017 | .243 | 13 | 73 | 0 | 0 | 0 | 0.00 | 0 |
| Jean Segura | 2017-2017 | .314 | 3 | 29 | 0 | 0 | 0 | 0.00 | 0 |
| Marcus Semien | 2016-2017 | .255 | 9 | 42 | 0 | 0 | 0 | 18.00 | 0 |
| Luis Severino | 2016-2016 | .000 | 0 | 0 | 0 | 0 | 0 | 5.40 | 4 |
| Travis Shaw | 2016-2017 | .204 | 7 | 24 | 0 | 0 | 0 | 0.00 | 0 |
| James Shields | 2016-2016 | .000 | 0 | 0 | 2 | 3 | 0 | 6.59 | 31 |
| Matt Shoemaker | 2016-2017 | .000 | 0 | 0 | 10 | 2 | 3 | 3.02 | 89 |
| Chasen Shreve | 2016-2017 | .000 | 0 | 0 | 5 | 7 | 5 | 3.24 | 129 |
| J.B. Shuck | 2016-2016 | 1.000 | 1 | 2 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Kevin Siegrist | 2016-2017 | .000 | 0 | 0 | 6 | 8 | 5 | 4.79 | 183 |
| Andrelton Simmons | 2016-2017 | .250 | 8 | 69 | 0 | 0 | 0 | 0.00 | 0 |
| Tony Sipp | 2016-2016 | .000 | 0 | 0 | 3 | 5 | 1 | 4.16 | 72 |
| Carson Smith | 2016-2017 | .000 | 0 | 0 | 5 | 4 | 3 | 2.58 | 121 |
| Joe Smith | 2016-2016 | .000 | 0 | 0 | 2 | 1 | 2 | 5.07 | 41 |
| Will Smith | 2016-2017 | .000 | 0 | 0 | 8 | 6 | 10 | 2.85 | 180 |
| Josh Smoker | 2016-2016 | .000 | 0 | 0 | 1 | 2 | 1 | 3.60 | 47 |
| Drew Smyly | 2016-2017 | .000 | 0 | 0 | 4 | 5 | 2 | 4.15 | 123 |
| Yangervis Solarte | 2016-2017 | .285 | 10 | 90 | 0 | 0 | 0 | 0.00 | 0 |
| Jorge Soler | 2016-2017 | .234 | 24 | 81 | 0 | 0 | 0 | 0.00 | 0 |
| Joakim Soria | 2016-2016 | .000 | 0 | 0 | 2 | 1 | 1 | 4.91 | 19 |
| Geovany Soto | 2016-2017 | .205 | 0 | 0 | 0 | 0 | 0 | 0.00 | 2 |
| Steven Souza Jr. | 2016-2017 | .237 | 8 | 25 | 0 | 0 | 0 | 0.00 | 0 |
| Denard Span | 2016-2017 | .275 | 6 | 52 | 0 | 0 | 0 | 0.00 | 0 |
| Cory Spangenberg | 2016-2017 | .290 | 11 | 108 | 0 | 0 | 0 | 0.00 | 0 |
| George Springer | 2016-2017 | .210 | 27 | 97 | 0 | 0 | 0 | 0.00 | 0 |
| Chris Squier | 2016-2017 | .165 | 2 | 25 | 0 | 0 | 0 | 0.00 | 0 |
| Giancarlo Stanton | 2016-2017 | .238 | 41 | 120 | 0 | 0 | 0 | 0.00 | 0 |
| Drew Storen | 2016-2017 | .000 | 0 | 0 | 2 | 3 | 2 | 3.73 | 40 |
| Trevor Story | 2017-2017 | .227 | 0 | 3 | 0 | 0 | 0 | 0.00 | 0 |
| Stephen Strasburg | 2016-2017 | .333 | 0 | 0 | 17 | 27 | 0 | 3.70 | 338 |
| Huston Street | 2016-2017 | .000 | 0 | 0 | 1 | 5 | 7 | 3.73 | 117 |
| Hunter Strickland | 2016-2017 | .000 | 0 | 0 | 2 | 9 | 6 | 4.14 | 98 |
| Marcus Stroman | 2016-2017 | .000 | 0 | 0 | 25 | 16 | 0 | 2.98 | 307 |
| Pedro Strop | 2016-2017 | .000 | 0 | 0 | 5 | 6 | 3 | 4.56 | 102 |
| Daniel Stumpf | 2017-2017 | .000 | 0 | 0 | 3 | 5 | 0 | 5.60 | 24 |
| Alixon Suarez | 2017-2017 | .300 | 0 | 1 | 0 | 0 | 0 | 0.00 | 0 |
| Eugenio Suarez | 2016-2017 | .243 | 20 | 89 | 0 | 0 | 0 | 0.00 | 0 |
| Andrew Susac | 2016-2017 | .213 | 5 | 18 | 0 | 0 | 0 | 0.00 | 0 |
| Ichiro Suzuki | 2016-2017 | .289 | 5 | 60 | 0 | 0 | 0 | 0.00 | 0 |
| Player | From-To | Avg | HR | RBI | W | L | SV | ERA | K |
| Kurt Suzuki | 2016-2017 | .184 | 1 | 19 | 0 | 0 | 0 | 0.00 | 0 |
| Blake Swihart | 2016-2017 | .282 | 13 | 65 | 0 | 0 | 0 | 0.00 | 0 |
| Noah Syndergaard | 2016-2017 | .000 | 0 | 0 | 19 | 14 | 0 | 3.19 | 384 |
